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Technical specifications
Control Parameters
| Analysis Parameter | Standard |
|---|---|
| Content (gas phase), % | 99.00% Min. |
| Refractive index | 1.4610-1.4630 |
| Moisture % | 0.5% Max. |
| Color (Hazen) | 40 Max. |
| Specific gravity (g/cm³, 20°C) | 1.070-1.085 |
| Appearance | Colorless transparent viscous liquid |
Basic Information
| Alternative Product Names | Diethyl ethoxymethylenemalonate |
| English name | Diethyl Ethoxymethylene Malonate |
| Molecular Formula | C₁₀H₁₆O₅ |
| Molecular weight | 216.23 |
| CAS No. | 87-13-8 |
| Packaging | 250 kg drum, 1250 kg IBC container, or as per customer request. |
| Storage | Store in a cool place, in tightly closed containers, in a dry, well-ventilated room. |
Product description
Product overview
Diethyl ethoxymethylene malonate is a colorless transparent viscous liquid, CAS number 87-13-8, molecular formula C₁₀H₁₆O₅, molecular weight 216.23, content (GC) ≥99.00%. It is an important pharmaceutical intermediate.
Product Features
- Content (GC) ≥99.00%, guarantee of high quality and purity.
- Moisture content ≤0.5%, low water content ensures stability.
- Color (Hazen) ≤40, clear and colorless appearance.
- Refractive index 1.4610-1.4630, quality indicators stable and controllable.
- Specific gravity 1.070-1.085 (20℃), stable physical properties
- Widely used in the field of pharmaceutical synthesis
Chemical Properties
Diethyl ethoxymethylenemalonate is an unsaturated ester compound containing an active methylene group. The ethoxymethylene group in its structure has high reactivity and can participate in various organic syntheses, such as Michael addition, Knoevenagel condensation, etc. This compound is important in the synthesis of pharmaceutical intermediates.
Area of application
Pharmaceuticals
An important pharmaceutical intermediate used for the synthesis of many active pharmaceutical ingredients such as quinolone antibacterials, pyrimidine compounds, etc.
Organic Synthesis
Used as an intermediate in organic synthesis in reactions such as Michael addition, Knoevenagel condensation, for synthesizing heterocyclic compounds containing pyridine, pyrimidine, and other rings.
Intermediates for Pesticides
Can be used to synthesize certain pesticide active ingredients, offering certain application value in the agrochemical field.
Fine Chemicals
In fine chemical synthesis, it is used to create functional molecules such as UV absorbers, photostabilizers, and other chemical products.
- Store in a cool place in tightly sealed containers
- Store in a dry, well-ventilated place
- Avoid high temperatures and direct sunlight
Frequently asked questions
Diethyl ethoxymethylenemalonate content in the product (GC) ≥99.00%, determined by gas chromatography, ensuring high purity. Each batch undergoes strict quality control before shipment and meets quality standard requirements.
The product's refractive index (20°C) is 1.4610–1.4630, and specific gravity is 1.070–1.085 g/cm³. These two physical parameters are important quality control indicators; values within the specified ranges confirm stable product purity and quality.
Product moisture ≤0.5% (max.), determined by Karl Fischer method. Low moisture content is critical for the stability of pharmaceutical intermediates, preventing product hydrolysis during storage and use, ensuring stable quality.
Color (Hazen) ≤40 — a measure of product transparency. The lower the Hazen value, the clearer the product. This product is a colorless clear viscous liquid; low color value indicates high purity, absence or minimal content of impurities and colored substances.
The molecular formula of diethyl ethoxymethylenemalonate is C₁₀H₁₆O₅, molecular weight 216.23. The structure contains two ethoxycarbonyl groups (-COOC₂H₅) and one ethoxymethylene group (-CH=CH-OCH₂CH₃). This unsaturated ester structure gives it high reactivity, allowing it to participate in various condensation and addition reactions.
The active methylene group (-CH=CH-O-) in diethyl ethoxymethylenemalonate can react with various nucleophiles, including: condensation with amines to form pyridine derivatives; Michael reaction with active methylene compounds; Knoevenagel condensation with carbonyl compounds. These reactions are important in the synthesis of heterocyclic compounds.
Under proper storage conditions (cool, dry place, sealed container), product shelf life can reach 12 months or more. Recommended storage at 15-25°C indoors, avoiding direct sunlight and high temperatures. Sealed packaging prevents moisture absorption and product evaporation.
As an organic solvent category product, it is recommended to work in a well-ventilated area. Avoid prolonged skin contact; in case of contact, rinse immediately with plenty of water. The product is a flammable liquid; keep away from ignition sources. For detailed safety information, refer to the Material Safety Data Sheet (MSDS).
Diethyl ethoxymethylenemalonate is soluble in various organic solvents including ethanol, diethyl ether, acetone, ethyl acetate, chloroform, etc. Poorly soluble in water. As an ester, it can undergo hydrolysis under strong acid or alkaline conditions.
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